Single nucleotide polymorphisms in Leishmania resistant to fluorinated pyrimidines

   Leishmaniasis, caused by Leishmania parasites, is a significant global health issue with limited treatment options. This study focuses on investigating the association between single nucleotide polymorphisms (SNPs) and resistance to fluorinated pyrimidines in Leishmania mexicana and Leishmania major. Multiple datasets were analyzed for each species, assessing resistance to specific drugs. The aim is to identify SNPs that contribute to drug resistance in Leishmania. Through full genome sequencing, numerous SNPs were detected in resistant cell lines compared to wild-type strains. The dataset provides comprehensive lists of high-confidence SNPs and their genomic positions. Further research is necessary to understand the functional implications of these SNPs and their role in conferring resistance to fluorinated pyrimidines. By exploring the molecular mechanisms of drug resistance, we can gain insights and potentially uncover new therapeutic targets for leishmaniasis.