Sodium Stibogluconate (Pentostam) induced Nephrotoxicity in Mice.

Pentavalent antimonials (Pentostam) (SSG) are one of the first-line drugs recommended by the Word

Health Organization (WHO) for treating leishmaniasis. The reported serious adverse effects after SSG

handling was cardiotoxicity, clinical pancreatitis and very few trials have reported renal side effects with

these compounds. The present study is aimed at evaluating the nephrotoxicity effect of sodium

stibogluconate (Pentostam) in mice. In addition to a control group, adult male albino mice were divided

into three groups, 7 mice each, and i.p. injected with 20mg/kg of pentostam for 14 days. After 14

therapeutic days. Group II, III and VI were sacrificed after 1, 3 and 6 weeks later. The mice’ serum and

kidney tissues were collected, and biochemical and histo-pathological studies were carried out.

Biochemical analysis of the serum obtained showed a significant increase in the levels of creatinine and

blood urea in group II and III when compared with control group. In parallel, the histo-pathological

assessments of the kidney tissue proved tubular necrosis. From this study, it can be concluded that the

antimonial pentostam has nephrotoxicity effect on treated mice.

                  أثبتت تقييمات أنسجة الكلى نخر أنبوبي.